Fig. 2: Metabolic reprogramming of cells with high motile potential. | Cell Death & Disease

Fig. 2: Metabolic reprogramming of cells with high motile potential.

From: Glioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase

Fig. 2

a KEGG pathway analysis of metabolism genes overexpressed in MHIGH cells versus MLOW cells highlights enrichment in pathways involved in energy production, oxidative stress response, extracellular matrix (ECM) modeling, and membrane composition rearrangements. BH-adjusted p-value < 0.05. N-S dataset analysis. b Inferred trajectory of GB cells from low to high motility. Cells colored by motility clusters (top panel) and motility score (bottom panel). MPST marks the path crossroad between low and high motile potential. N-S dataset analysis. c MPST overexpression in GB tissues (n = 163) versus normal brain tissues (n = 207). TCGA RNA-seq dataset, GEPIA2 website. One-way ANOVA test, *BH-adjusted p-value < 0.05. d Schematic representation of the metabolic pathways overrepresented in MHIGH cells compared to MLOW cells (created with BioRender.com). See also Tables S4 and S5.

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