Fig. 7: USF2 is downregulated in HCC and negatively associated with TXNRD1 expression. | Cell Death & Disease

Fig. 7: USF2 is downregulated in HCC and negatively associated with TXNRD1 expression.

From: USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling

Fig. 7

A Dot density plots show USF2 mRNA level in normal or tumorous HCC samples determined by microarray analysis. Different datasets from the Oncomine database were analyzed. B USF2 expression in 50 paired samples of tumorous tissues and nontumorous adjacent normal liver tissues from patients with HCC in TCGA cohort. C Kaplan-Meier analysis for overall survival was performed according to USF2 levels in TCGA cohort. D Protein levels of p-Akt, USF2 and TXNRD1 were examined by western blot analysis in six paired samples from patients with HCC. E Dot plot showing the correlation between the mRNA levels of TXNRD1 and USF2 in the TCGA LIHC panel. F Schematic depiction of mechanisms underlying USF2-mediated upregulation of TXNRD1 contributes HCC proliferation and metastasis via Akt/mTOR activation. Data represent the mean ± SD. *P < 0.05, ***P < 0.001. P values were calculated by Student’s t test (A), Paired t test (B), log-rank test (D), Pearson’s correlation coefficient(E).

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