Fig. 2: Quantification of molecular species and acyl composition of cardiolipin (CL) in the injured spinal cord at 3 and 24 h after SCI. | Cell Death & Disease

Fig. 2: Quantification of molecular species and acyl composition of cardiolipin (CL) in the injured spinal cord at 3 and 24 h after SCI.

From: Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury

Fig. 2

A Quantification of CL molecular species at 3 and 24 h after SCI. Over 50 distinct CL molecular species were readily identified. Of them, 50% of species of CL were significantly reduced after SCI. *P < 0.05, **P < 0.01 vs. sham (Two-way ANOVA, Tukey’s multiple comparisons test, n = 4 rats/groups). Data represent mean ± s.e.m. The x-axis is mass-to-charge ratio (m/z). B, C Quantification of acyl composition in CL species at 3 and 24 h after SCI. 18:1 fatty acid was predominantly composed of CL and was 49.86% of CL compositions. The following enrichment of acyl was 20:4 (AA, 18.99%), 22:6 (DHA, 12.29%) and 18:2 (LA, 8.08%). After SCI, all decreased CL acyls were unsaturated fatty acids; of them, 50% were poly-unsaturated fatty acids. *P < 0.05, **P < 0.01 vs. sham (Two-way ANOVA, Tukey’s multiple comparisons test, n = 4 rats/groups). Data represent mean ± s.e.m.

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