Fig. 6: The progression of T-ALL was significantly delayed after FGF2/FGFR2 blockade in vivo. | Cell Death & Disease

Fig. 6: The progression of T-ALL was significantly delayed after FGF2/FGFR2 blockade in vivo.

From: Blockade of FGF2/FGFR2 partially overcomes bone marrow mesenchymal stromal cells mediated progression of T-cell acute lymphoblastic leukaemia

Fig. 6

A The engraftments of T-ALL cells in PB were significantly decreased on day14 after model establishment when the mice were injected intraperitoneally with BGJ398. B The engraftments of T-ALL cells in BM were similarly prominently decreased on day14 after model establishment when FGF2 and FGFR2 combination was disrupted. C The dynamic monitoring of the proportion of T-ALL cells in PB and BM were summarised. D The size and weight of spleen from FGF2/FGFR2 blockade mice were reduced on day14 after model establishment. E The size and weight of liver from FGF2/FGFR2 blockade mice was shrunk on day14 after model establishment. F To intuitively understand the changes of the number of normal HSCs and HPCs in BM of T-ALL after FGF2/FGFR2 blockade, FACS was used and results showed that both number of them were decreased. (n ≥ 3, *P < 0.05, **P < 0.01, ***P < 0.005).

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