Fig. 7: Attenuated depression-like behavior deficit in TgAPP_swe^HSA mice treated with senescence inhibitors.

A, B RT-PCR analysis of indicated gene expression in the TA muscles (A) and hippocampus (B) of 6-MO control and TgAPP_swe^HSA mice with Veh or DQ treatments, data are present as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, n = 4 mice/group, one-way ANOVA followed by Sidak’s multiple comparisons post hoc test was used. C Summaries of DQ drugs’ effect on the factors tested in serum in Fig. S14. each dot represents different factors, and relative fold change over control mice treated with vehicle was shown, two-way ANOVA followed by Sidak’s multiple comparisons post hoc test was used. D A schematic diagram of the experimental design and the quantifications of depression-like behaviors using TST, FST, and SPT. 6-MO control (LSL-APP_swe,, males) and TgAPP_swe^HSA mice were treated with Veh (10%PEG 400) or DQ (D 5 mg/kg, Q 50 mg/kg, dissolved in 10% PEG 400, once per two weeks), starting at age of 3-MO, and then subjected to indicated behavior tests at 6-MO. All data are presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001. n = 8–13 mice per group, two-way ANOVA followed by Sidak’s multiple comparisons post hoc test. E An illustration of the working model.