Fig. 1: EC Casp9 deletion rescues contrast sensitivity one day P-RVO. | Cell Death & Disease

Fig. 1: EC Casp9 deletion rescues contrast sensitivity one day P-RVO.

From: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline

Fig. 1

A Experimental schematic. Two-month-old iEC Casp9 WT/KO mice were treated with tamoxifen for five consecutive days. After two days of rest, their optokinetic response was tested pre and one-day P-RVO. Created with BioRender.com. B Optokinetic test was performed by testing their contrast sensitivity at three acuity settings: 0.05, 0.15, 0.25 cycles/°. C–D Contrast sensitivity and visual acuity values prior to RVO of uninjured iEC Casp9 WT (n = 14–15) and KO (n = 14–19). E Contrast sensitivity response of uninjured iEC Casp9 WT (n = 7) and KO (n = 8), and iEC Casp9 WT (n = 11) and KO (n = 12) one-day P-RVO at 0.05, 0.15, 0.25 cycles/°. *P ≤ 0.05, Error bars mean ± SEM, Two-way ANOVA, Fisher’s LSD test. F Contrast sensitivity correlated with fractions of veins occluded, linear regression n = 12.

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