Fig. 7: Astro Casp9 deletion reduces capillary ischemia and contrast sensitivity decline. | Cell Death & Disease

Fig. 7: Astro Casp9 deletion reduces capillary ischemia and contrast sensitivity decline.

From: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline

Fig. 7

A Representative retinal fundus and OCT images of DRIL of uninjured and one day P-RVO iAstro Casp9 WT and KO. Red strikes present DRIL areas. B Percentage of DRIL of uninjured and one day P-RVO iAstro Casp9 WT and KO. C Simple linear regression of DRIL vs fractions of veins occluded. D Timeline of fractions of veins occluded of iAstro Casp9 WT and KO. Astro Casp9 deletion rescues contrast sensitivity one day P-RVO. E–F Contrast sensitivity and visual activity values prior to RVO of uninjured iAstro Casp9 WT (n = 21) and KO (n = 15). G Contrast sensitivity response of uninjured iAstro Casp9 WT (n = 19) and KO (n = 20), and iAstro Casp9 WT (n = 16) and KO (n = 16) one day P-RVO at 0.0, 0.15, 0.25 25 cycles/°. Error bars mean ± SEM, Two-way ANOVA, Fisher’s LSD test. H Simple linear regression of contrast sensitivity at 0.05 cycles/° vs fraction of veins occluded at one day P-RVO. *P ≤ 0.05 and ***P ≤ 0.001.

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