Fig. 7: Gene therapy with circFOXO3 preserves articular cartilage integrity in a mouse OA model. | Cell Death & Disease

Fig. 7: Gene therapy with circFOXO3 preserves articular cartilage integrity in a mouse OA model.

From: CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy

Fig. 7

A Schematic of the animal experiments (for each group, n = 6, C57BL/6). B X-ray and 3D reconstruction images of micro- CT scanning of the knees. Scale bars, 2 mm and 1 mm. C OARSI scoring was performed according to staining results. (n = 6) *p < 0.05. D Safranin-O/fast green staining, H&E staining, TUNEL staining, IHC staining and IF staining of cartilage from different groups. Scale bars, 20 μm. E Safranin-O/fast green staining, H&E staining, TUNEL staining and IHC staining of cartilage from different groups. Scale bars, 20 μm. F Graphic abstract of our study.

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