Fig. 4: Mybpc3 disruption enhanced aerobic glycolysis in fibroblasts.
From: MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis
A–E Analysis of glycolytic flux by measurements of glucose concentrations (A, B), lactate secretion (C, D), and ATP production (E). **P < 0.01; ***P < 0.001; ****P < 0.0001. F, G Western blot analysis of key glycolytic enzymes in WT and MYBPC3-KO cells treated with or without 2-DG (5 mM). H qRT-PCR analysis of key glycolytic enzymes genes in WT and MYBPC3-KO cells treated with or without 2-DG (5 mM). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns, not significant.
