Fig. 1: Prognostic significance of 5-hmC level and the proportion of SP cells in HCC. | Cell Death & Disease

Fig. 1: Prognostic significance of 5-hmC level and the proportion of SP cells in HCC.

From: Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis

Fig. 1

A Representative IHC staining images of differential 5-hmC levels in 101 HCC and adjacent nontumor tissues. B The staining level of 5-hmC in HCC tumor tissue was significantly weaker than paired adjacent normal tissue; Wilcoxon matched-pairs signed-rank test, ***P < 0.001. C Kaplan–Meier estimate of overall survival rate of 101 HCC patients with different levels of 5-hmC; Log-rank test, ***P < 0.001. D Kaplan–Meier estimate of cumulative recurrence rate of 101 HCC patients with different levels of 5-hmC; Log-rank test, ***P < 0.001. E Kaplan–Meier estimate of the overall survival rate of 101 HCC patients with different proportions of SP cells; Log-rank test, P = 0.039. F Kaplan–Meier estimate of cumulative recurrence rate of 101 HCC patients with different proportions of SP cells; Log-rank test, P = 0.003. G The staining level of 5-hmC in SP high groups was significantly weaker than in SP low; Wilcoxon rank-sum test, P = 0.003. H Estimation of correlation between 5-hmC staining level and the proportion of SP cells in tumor tissues; Spearman rank correlation, r = −0.35, P < 0.001.

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