Fig. 1: General characteristics of mutp53.
From: Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
a p53 is composed of amino-terminal transcription activation domain (TAD), DNA binding domain (DBD) and carboxy-terminal tetramerization domain (TD). The main mutant types of TP53 include missense mutations, truncating mutations, inframe mutations, and splice mutations. b Different mutation types caused by different mechanisms and its impact on tumor development. c Structure of p53 core domain and common mutation sites (R175, G245, R248, R249, R273, R282). Figure adapted from RCSB PDB (PDB 2AC0). d Common substitution mutations shown in the COSMIC Database. e Mutation frequency of p53 in different tumors.
