Fig. 1: TINCR was highly expressed in liver tissues and CSCs. | Cell Death & Disease

Fig. 1: TINCR was highly expressed in liver tissues and CSCs.

From: The long noncoding RNA TINCR promotes self-renewal of human liver cancer stem cells through autophagy activation

Fig. 1

A TINCR expression levels in HCC tissues were assessed by qRT-PCR assay. TINCR expression in tumor tissues were higher than the matched normal tissues (p < 0.01). B The patients with III/IV stage exhibited higher TINCR expression in tumor tissues than those with stage I/II. C TINCR expression was determined by ISH assay. Representative images of TINCR in HCC and adjacent tissue are shown. Scale bar, 100 μm. D RFS and OS of HCC patients in validation cohort. Patients with positive TINCR expression had shorter RFS (p = 0.003) and OS (p = 0.004). E CD133+CD13+ subpopulations were sorted by flow cytometry from HCCLM3, MHCC97H HCC cell lines, and primary tumor cells. F Typical microscope images of spheres in HCCLM3 cells. Scale bar, 100 mm. G TINCR was detected in LCSCs and non-LCSCs by qRT-PCR assay. H TINCR expression levels were examined in oncosphere and non-oncosphere cells. Data are shown as means ± SD and represent at least three independent experiments. **p < 0.01, ***p < 0.001.

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