Fig. 3: Overexpressed TINCR enhanced tumorigenic capacity of LCSCs. | Cell Death & Disease

Fig. 3: Overexpressed TINCR enhanced tumorigenic capacity of LCSCs.

From: The long noncoding RNA TINCR promotes self-renewal of human liver cancer stem cells through autophagy activation

Fig. 3

A TINCR stably overexpressed HCC primary tumor cells and cell lines were established. (B) TINCR overexpression promoted sphere formation of HCC cell lines and primary cells. Scale bar, 100 mm. C Expression of transcription factors were elevated in TINCR-overexpressing HCC cells. D TINCR overexpressed primary tumor cells were diluted and subcutaneously implanted into BALB/c mice. n = 6 for each group. (E) After subcutaneous implantation, the average tumor volumes in each groups were calculated. F Fluorescence signals of liver orthotopic tumor from TINCR-overexpressing and empty vector groups were captured. G TINCR-overexpressing promoted lung metastasis rate. Data are shown as means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.

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