Fig. 3: The transcriptional changes of NaIO3-induced RPE sheet. | Cell Death & Disease

Fig. 3: The transcriptional changes of NaIO3-induced RPE sheet.

From: IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation

Fig. 3

A Heatmap showing differentially expressed inflammation-related genes in NaIO3 mice with and without IL-4 treatment. The pro-inflammatory genes such as Cxcr2, Cxcl1, Cxcl10, Stat1, Ccl8, etc were down-regulated in the IL-4-treated group, while the anti-inflammatory genes, including Il1f5, Klf14, Drd5, Ifnk, etc were upregulated. B GSEA analysis revealed significantly enriched gene sets such as axon extension and neurogenesis in the IL-4 group, and the enriched gene sets, including the inflammation and oxidative stress-related gene sets in the NaIO3-RPE without IL-4. n = 3, FDR value <0.25. C The enrichment analysis of IL-4Rα and anti-oxidative genes such as Nrf2, Hmox1, and Arg1 in different groups were presented by circos plot. The thickness and color of the ribbons correlated to the genes expression.

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