Fig. 7: LINC00924 promotes matrix-detached GC cells survival and metastasis in vitro and in vivo. | Cell Death & Disease

Fig. 7: LINC00924 promotes matrix-detached GC cells survival and metastasis in vitro and in vivo.

From: LINC00924-induced fatty acid metabolic reprogramming facilitates gastric cancer peritoneal metastasis via hnRNPC-regulated alternative splicing of Mnk2

Fig. 7

A 3D spheroid formation assay of MGC803-NC and LINC-OE cells. Results were quantified as fold changes. B 3D spheroid formation assay of AGS-NC and LINC-KD cells. Results were quantified as fold changes. C Live and dead staining of MGC803-NC and LINC-OE cells after culture on 3D ultralow attachment plates for 6 days (with live cells stained in green and dead cells stained in red). Results were quantified as fold changes. D Live and dead staining of AGS-NC and LINC-KD cells after culture on 3D ultralow attachment plates for 6 days (with live cells stained in green and dead cells stained in red). Results were quantified as fold changes. E 3D spheroid formation assay of MGC803-NC and LINC-OE cells treated or not treated with GW6471. Results were quantified as fold changes. F Live and dead staining of AGS-NC and LINC-KD cells treated or not treated with GW6471 after culture on 3D ultralow attachment plates for 6 days (with live cells stained in green and dead cells stained in red). Results were quantified as fold changes. G The morphological characteristics of subcutaneous tumor xenografts in the AGS-NC and LINC-KD groups. H Subcutaneous tumor volume in the AGS-NC and LINC-KD groups. I Subcutaneous tumor weight in the AGS-NC and LINC-KD groups. J The morphological characteristics of peritoneal tumor xenografts in the LINC-NC, LINC-OE, LINC-OEā€‰+ā€‰hnRNPC-NC and LINC-KDā€‰+ā€‰hnRNPC-KD groups.

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