Fig. 2: SWI/SNF alters cellular chromatin polarity.

A ATAC-seq read-density heatmaps from U87MG cells overexpressing SMARCC2 for indicated durations (n = 2 biological replicates). B Genome-wide annotation of chromatin accessibility after overexpression of SMARCC2 in U87MG cells. C RNA-seq MA plot showing up (red)- and down (green)-regulated genes in the genome upon overexpression of SMARCC2 in U87MG cells. D Combined analysis of ATAC-seq and RNA-seq data to screen for genes with downregulated mRNA expression and reduced chromatin polarity (above, left), and another part of genes with upregulated mRNA expression and increased chromatin polarity (above, right). Specific gene names were presented in tabular form (under). E Representative screenshot in U87MG cells showing obviously changes in DKK1 upon SMARCC2 overexpression. F KEGG enrichment analysis of the above-changed genes.