Fig. 1: MSCs-IT alleviated imiquimod (IMQ) induced psoriasis-like inflammation of mice. | Cell Death & Disease

Fig. 1: MSCs-IT alleviated imiquimod (IMQ) induced psoriasis-like inflammation of mice.

From: Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis

Fig. 1

WT mice received subcutaneous injection with 2 × 106 MSCs, MSCs-IT in 150 µL PBS, or 150 µL PBS alone on days 1 and 4 of IMQ application. Mice were euthanized on the 7th day (n = 3–5 mice for each group). A The experimental scheme. B H&E staining of the lesions in each group; the Ki-67 immunostaining of skin in the indicated groups. C Measurement of epidermal thickness. D The statistics of Ki-67 positive cells. E PASI scores of mice in the indicated groups. F The splenic index (The spleen weight/The body weight) in each group. Scale bars: 50 µm. Data were shown as means ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: not significant.

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