Fig. 3: Neutrophil depletion attenuated psoriatic inflammation. | Cell Death & Disease

Fig. 3: Neutrophil depletion attenuated psoriatic inflammation.

From: Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis

Fig. 3

The psoriatic mice were randomly assigned into two groups. They were either injected with 50 µg anti-mouse Gr-1 or isotype control antibody (n = 5 mice for each group). The anti-mouse Gr-1 was injected intraperitoneally every other day from days −2 to 7. Skin samples on day 7 were for H&E staining and flow cytometry. A The experimental scheme. B Flow cytometry analysis of neutrophils in the indicated groups. C The Ly6G immunostaining of the skin; enumeration of Ly6G positive cells. D H&E staining of the skin in the indicated groups; measurement of epidermal thickness. E The Ki-67 immunostaining of the skin in both groups; enumeration of Ki-67 positive cells. F The PASI scores were monitored daily in the indicated groups during the entire experiment. Data were shown as means ± SEM. Scale bars: 50 µm. *p < 0.05, **p < 0.01, ****p < 0.0001.

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