Fig. 1: circFNDC3B is downregulated in CRC tissues and cells, and low circFNDC3B expression is associated with unfavorable overall survival in CRC patients. | Cell Death & Disease

Fig. 1: circFNDC3B is downregulated in CRC tissues and cells, and low circFNDC3B expression is associated with unfavorable overall survival in CRC patients.

From: m6A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation

Fig. 1

A Schematic drawing illustrated the formation of circFNDC3B. B, C The expression level of circFNDC3B was detected by qRT-PCR in LoVo and HCT116 cells treated with Actinomycin D or RNase R. D The circFNDC3B level in CRC tissues was detected by qRT-PCR. E The correlation between circFNDC3B level and OS of CRC patients was analyzed by Kaplan–Meier method. F The circFNDC3B level in CRC cells was detected by qRT-PCR. G The circFNDC3B level in LoVo and HCT116 cells was detected by subcellular fractionation. H The subcellular localization of circFNDC3B was detected by RNA FISH in LoVo and HCT116 cells. Scale bar, 10 μm; Green, circFNDC3B; Blue, DAPI. **P < 0.01, ***P < 0.001.

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