Fig. 9: Overexpression of circFNDC3B or RNF41 suppresses tumor growth, stemness and liver metastasis via modulating ASB6 in vivo. | Cell Death & Disease

Fig. 9: Overexpression of circFNDC3B or RNF41 suppresses tumor growth, stemness and liver metastasis via modulating ASB6 in vivo.

From: m6A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation

Fig. 9

A Photographs of xenograft tumors. B Quantitative analysis of tumor volume. C Quantitative analysis of tumor weight. D–H The mRNA levels of RNF41, OCT4, Nanog, SOX2, and CD133 in xenograft tumors were detected by qRT-PCR. I The protein levels of ASB6, OCT4, Nanog, SOX2, and CD133 were detected by western blotting with quantitative analysis. J The immunoreactivities of Ki-67, CD133, and ASB6 in xenograft tumors were detected by IHC analysis. K Representative photographs of liver tissues derived from in vivo liver metastasis mice model. L The histological changes of liver tissues were detected by H&E staining. *P < 0.05, **P < 0.01, ***P < 0.001.

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