Fig. 4: J2H-1702 ameliorates steatosis and fibrosis in MCD diet-induced NASH mice. | Cell Death & Disease

Fig. 4: J2H-1702 ameliorates steatosis and fibrosis in MCD diet-induced NASH mice.

From: Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH

Fig. 4

Male C57BL/6 N mice were fed a normal chow diet (normal control) or an MCD diet to induce NASH and treated with 10 mg/kg OCA or 10 or 30 mg/kg J2H-1702. A Level of 11βHSD1 were increased in MCD-diet mouse livers in IHC staining. B, C ALT and AST levels were measured from collected plasma B and liver TC and TG levels were measured from hepatic tissues extracted at autopsy. D, E Oil Red O staining D and hydroxyproline staining E were performed, from which steatosis and fibrosis areas were measured. Values are expressed as mean ± SD (n = 10). ***P < 0.001 compared to the normal control group, #P < 0.05, ##P < 0.01 and ###P < 0.001 compared to the MCD-diet vehicle control group.

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