Fig. 5: J2H-1702 ameliorates steatosis and fibrosis in AMLN diet-induced NASH mice. | Cell Death & Disease

Fig. 5: J2H-1702 ameliorates steatosis and fibrosis in AMLN diet-induced NASH mice.

From: Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH

Fig. 5

Male C57BL/6 N mice were maintained on an AMLN diet for 30 weeks and continued on the same diet during 12-week oral treatment with 30 mg/kg OCA or 3, 10, or 20 mg/kg J2H-1702. A Cortisol levels of liver tissues were estimated. B, C AST and ALT B, LDL, TC, and TG C levels were measured from collected mice plasma. D Liver TC and liver TG levels were measured from hepatic tissues obtained at autopsy. Values are expressed as mean ± SEM (n = 10). ###P < 0.001, ####P < 0.0001 vs Lean chow, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001 vs. AMLN diet-fed control. One-way ANOVA followed by Dunnett’s test.

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