Fig. 6: CPX inhibits tumor growth in a mouse xenograft model of GC.
From: Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells
A–D Tumor-bearing nude mice of MGC, AGS, and SGC cells (4 mice per group) were intraperitoneally injected with 0.9% NaCl or CPX (20 mg/kg), respectively. Images of dissected tumors from tumor-bearing mice were shown (A). Tumor volume was measured once in 2 days (B). Tumor weight was measured after 12 days of consecutive injections (C). Changes in the mean body weight from mice treated with 0.9% NaCl or CPX (D). Data were shown as mean ± SD (n = 4, *P < 0.05, **P < 0.01, or n.s., not significant by unpaired Student’s t test). E Images of immunohistochemistry staining of Ki67, LC3, STAT3, and p-STAT3 (Tyr705) in the tumor of GC mouse xenograft model intraperitoneally injected with 0.9% NaCl or CPX (Scale bar, 100 µm).
