Fig. 7: The proposed antitumorigenic mechanism of CPX on GC growth.
From: Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells
CPX treatment induces cell cycle arrest and then inhibits GC cell proliferation by regulating the p-Src (Tyr416)/p-STAT3 (Tyr705) pathway. Moreover, CPX enhances autophagic death by inducing total STAT3 ubiquitination and decreasing p-STAT3 (Ser727) levels in GC cells.
