Fig. 6: LV-ETS1 Exos promote the proliferation, migration, and invasion of ovarian cancer cells via remodeling macrophages. | Cell Death & Disease

Fig. 6: LV-ETS1 Exos promote the proliferation, migration, and invasion of ovarian cancer cells via remodeling macrophages.

From: Laminins in tumor-derived exosomes upregulated by ETS1 reprogram omental macrophages to promote omental metastasis of ovarian cancer

Fig. 6

A A sketch illustrating the experimental design. M0 macrophages treated with LV-ETS1 Exos and LV-GFP Exos for 48 h. The effect of the conditioned medium from macrophages treated with exosomes on the proliferation, migration, and invasion of ovarian cancer cells were analyzed by CCK-8 assay, colony-formation assay, Transwell assay and wound-healing assay. B The effect of conditioned medium of macrophages treated with LV-ETS1 Exos and LV-GFP Exos on HO-8910 and A2780 cell proliferation was measured by CCK-8 assay. C The effect of conditioned medium of macrophages treated with LV-ETS1 Exos and LV-GFP Exos on HO-8910 and A2780 cells proliferation was measured by colony-formation assay. D The effect of conditioned medium of macrophages treated with LV-ETS1 Exos and LV-GFP Exos on HO-8910 and A2780 cell migration and invasion were analyzed by Transwell assay. E Wound-healing assay showing the horizontal migration ability of ovarian cancer cells co-cultured with conditioned medium of macrophages treated with LV-ETS1 Exos and LV-GFP Exos. Data are shown as mean ± SD. *P < 0.05, **P < 0.01.

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