Fig. 6: TFBS motifs identified in significant ATAC-seq peaks associated with cluster C1 genes and expression of the corresponding TF genes in O4+ cell populations and the Oli-neu cell line. | Cell Death & Disease

Fig. 6: TFBS motifs identified in significant ATAC-seq peaks associated with cluster C1 genes and expression of the corresponding TF genes in O4+ cell populations and the Oli-neu cell line.

From: Epigenetic priming of immune/inflammatory pathways activation and abnormal activity of cell cycle pathway in a perinatal model of white matter injury

Fig. 6

A TFBS motif analysis reveals the presence of TF binding motifs of the immune/inflammatory pathways in significant ATAC-seq peaks that are adjacent to the upregulated genes (UP) correspond to TF of gene cluster C1. TFBS were identified using HOMER known motifs. (See also Fig. S5). B Heat map illustrating the expression of TFs of the IRF and NFκB families in O4+ cell populations. Microarray data from microglia [9]; n = 3 PBS samples and n = 3 IL1B samples isolated from the same cortices and at the same stage is given for comparison. M: Microglia. O_P5: O4+ cells at P5. O_P10: O4+ cells at P10. C The oligodendroglial Oli-neu cell line recapitulates the expression of TF genes of the immune/inflammatory pathways in physiological and inflammatory conditions. As in Fig. 4C. Cyclin-dependent kinase 6 (Cdk6) mRNA levels were analyzed in parallel.

Back to article page