Fig. 6: XPA knockout combats the enzalutamide resistance.
A–C LNCaP/ENZ cells (1 × 106) were infected with lentivirus expressing sgSCR and sgXPA and then injected subcutaneously into the flank of 8-week-old male castrated mull mice. When tumor size reached ~50 mm3, mice were administered with the vehicle (10% DMSO plus 90% corn oil mixture as control, n = 10), ENZ (10 mg/kg, i.g.) (A). Tumor volume (n = 10) (B) and survival (n = 10) (C) were monitored as indicated days. Data are presented as means ± s.e.m. Statistical analysis for tumor growth and overall animal survival were performed using two-way ANOVA analysis (B) and Log-rank (Mantel-Cox) test analysis (C), respectively. The asterisks indicate significant differences between the indicated groups (*p < 0.05, ***p < 0.001).
