Fig. 7: Schematic diagram of the DDX17/miR-149-3p/CYBRD1 signaling pathway in the modulation of EMT and CRC progression. | Cell Death & Disease

Fig. 7: Schematic diagram of the DDX17/miR-149-3p/CYBRD1 signaling pathway in the modulation of EMT and CRC progression.

From: DDX17 induces epithelial-mesenchymal transition and metastasis through the miR-149-3p/CYBRD1 pathway in colorectal cancer

Fig. 7

DDX17 is elevated in CRC and decreases the expression of miR-149-3p independent of DDX17’s Microprocessor function. Downregulated miR-149-3p attenuates its binding to the 3′-UTR of CYBRD1 mRNA, leading to increases CYBRD1 expression and intracellular iron level, which promotes EMT progression and metastasis of CRC cells.

Back to article page