Fig. 6: Integrated proteotranscriptomics analysis revealed that SLC1A5 regulated ferroptosis state by affecting the expression of GPX4. | Cell Death & Disease

Fig. 6: Integrated proteotranscriptomics analysis revealed that SLC1A5 regulated ferroptosis state by affecting the expression of GPX4.

From: SLC1A5 enhances malignant phenotypes through modulating ferroptosis status and immune microenvironment in glioma

Fig. 6

A The differentially expressed genes between shCtrl and sh-SLC1A5 groups through RNA-sequence. B GSEA analysis showed the correlation between the differentially expressed genes and ferroptosis pathway. C The mRNA expression of ferroptosis-related genes in the shCtrl and sh-SLC1A5 group. D The differentially expressed proteins between shCtrl and sh-SLC1A5 group through TMT-proteomics analysis. E The expression of ferroptosis-related proteins in the shCtrl and sh-SLC1A5 group. The Western Blot indicating the expression of GPX4 in T98G and U87 cell lines after SLC1A5 knockdown (F) or overexpression (G) by Western Blot.

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