Fig. 8: SLC1A5 modulated THP-1 derived macrophages infiltration and its inhibitor synergized with immune checkpoint inhibitor to suppress tumor growth.

A, C The migration of THP-1 derived macrophages co-cultured with different groups of GBM cells (Scale Bar = 20 μm). B, D Flow cytometry results representing the percent of CD11b⁺ CD206⁺ macrophages after co-cultured with different groups of GBM cells. E Relative mRNA expression of CD163 and LYVE1 (M2 macrophage markers) in THP-1 derived macrophages co-cultured with different groups of GBM cells. F–H The HE staining and tumor size analysis of mice in PD-1mAb and V9302 separate or combined treatment group (Scale Bar = 1 mm). G The survival time of GL261-bearing C57BL/6 mice under different treatments.