Fig. 6: AT7519 inhibits tumor growth in glioblastoma xenograft mice. | Cell Death & Disease

Fig. 6: AT7519 inhibits tumor growth in glioblastoma xenograft mice.

From: The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest

Fig. 6

A Image of the subcutaneous xenograft tumors formed in nude mouse models. B Tumor volumes were measured and calculated every week. ****P < 0.0001 as assessed by two-way ANOVA followed by Sidak’s multiple test. C Tumors were excised and weighed at the end of the experiment. ***P < 0.001 by Student’s t-test. D Body weight of nude mice during administration of AT7519. E Representative H&E-stained images of the intracranial xenograft model in the AT7519 treatment group and control group. *p < 0.05 as assessed by Student’s t-test. F Western blot assay of the apoptosis, pyroptosis, and cell cycle-related key protein expression levels in tumor tissue. G Schematic model of the antitumor mechanism of AT7519 in glioblastoma cells.

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