Fig. 3: Mice deficient in E13 have a shortened lifespan and are prone to spontaneous tumors, chronic inflammation and liver steatosis. | Cell Death & Disease

Fig. 3: Mice deficient in E13 have a shortened lifespan and are prone to spontaneous tumors, chronic inflammation and liver steatosis.

From: TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response

Fig. 3

A Kaplan-Meyer survival curves of WT (n = 56), Trp73+/− (n = 30), and E13+/− (n = 31) mice. B Tumor spectra in WT (n = 56), Trp73+/− (n = 27), and E13+/− (n = 29) mice. C Representative images of H.E. stained kidney, lung and pancreas tissues from WT and E13+/− mice. D Percentage of WT, Trp73+/−, and E13+/− mice with inflammation in 3 or more organs. E Representative images of H.E. stained liver tissues from WT and E13+/− mice. F Percentage of WT, Trp73+/−, and E13+/− mice with liver steatosis.

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