Fig. 1: PLK1 and AURKB levels in TNBC are higher in AAs than in EAs. | Cell Death & Disease

Fig. 1: PLK1 and AURKB levels in TNBC are higher in AAs than in EAs.

From: PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer

Fig. 1

Bar graphs showing mitosis scores in the Emory (A) and Dekalb (B) cohorts. C Heatmap showing the expression levels of various kinases in the TCGA BC dataset. D, E Bar graphs showing the expression levels of PLK1 (D) and AURKB (E) in AA (n = 3) and EA (n = 3) TNBC cell lines. F–H Representative IHC images of PLK1 and AURKB (F) and quantification bar graphs showing PLK1 (G) and AURKB (H) levels in grade- and stage-matched AA and EA patients with TNBC (Dekalb cohort). I Immunoblot showing PLK1 and AURKB protein levels in AA and EA TNBC cell lines (n = 3 each). FPKM fragments per kilobase of transcript per million mapped reads. Bars indicate mean ± SEM. Unpaired two-tailed Student’s t-test with Welch’s correction was used to determine statistical significance (*P < 0.05, ***P < 0.0005, ns = non-significant). The scale bar represents 100 µm.

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