Fig. 5: Inhibition of PLK1 and AURKB suppresses tumor growth and improves survival in nude mice bearing AA TNBC tumors. | Cell Death & Disease

Fig. 5: Inhibition of PLK1 and AURKB suppresses tumor growth and improves survival in nude mice bearing AA TNBC tumors.

From: PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer

Fig. 5

A Schematic diagram showing the treatment schedule for volasertib (green arrow) and barasertib (red arrow) in mice bearing AA and EA TNBC xenografts. B–F Representative tumor images (B), changes in tumor volume in AA (C) and EA (F) tumors, and tumor growth inhibition in mice with AA (n = 12) (D) and EA (n = 12) (G) TNBC xenografts. E, H Kaplan–Meier plots showing survival in mice bearing AA (n = 12) (E) and EA (n = 12) (H) xenografts. Bars indicate mean ± SEM. Unpaired two-tailed Student’s t-test with Welch’s correction was used to determine statistical significance (*P < 0.05, **P < 0.005, ****P < 0.00005, ns = non-significant).

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