Fig. 6: Inhibition of PLK1 and AURKB decreases Ki-67 and p-survivin levels in mice bearing AA TNBC tumors. | Cell Death & Disease

Fig. 6: Inhibition of PLK1 and AURKB decreases Ki-67 and p-survivin levels in mice bearing AA TNBC tumors.

From: PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer

Fig. 6

A–F Representative IHC images (A, B) and bar graphs (C–F) showing Ki-67 and survivin levels in AA (C, E) and EA (D, F) TNBC xenografts under various treatment conditions. G, H Immunoblots showing the levels of p-survivin (T117), p-survivin (S20), total survivin, AURKB, PLK1, and β-actin in AA (G) and EA (H) fresh-frozen xenograft tumor lysates from mice treated with volasertib, barasertib, or their combination (n = 12 per treatment group). Bars represent mean ± SEM. Unpaired two-tailed Student’s t-test with Welch’s correction was used to determine statistical significance (****P < 0.00005, ns = non-significant). The scale bar represents 100 µm.

Back to article page