Fig. 2: SERPINE1 was increased in both circulation and tumors of DIO syngeneic TNBC mice. | Cell Death & Disease

Fig. 2: SERPINE1 was increased in both circulation and tumors of DIO syngeneic TNBC mice.

From: Obesity promotes radioresistance through SERPINE1-mediated aggressiveness and DNA repair of triple-negative breast cancer

Fig. 2

A Sera from C57BL/6 female mice fed with CD or HFD for 4 weeks were pooled and subjected to an adipokine array to identify the candidate adipokines that were related to DIO. N = 7 in each group. B Serum level of Serpine1 from both CD and HFD groups of mice were measured by ELISA. C Correlation between Serpine1 level and tumor weight in the mice fed with CD or HFD. D IHC staining of Serpine1 level in the tumor sections in each group of mice. 10 fields from 3 tumor sections were analyzed for each group. Representative images were shown on the right panel. Scale bar: 20 μm. E, F Tumor volume was measured every 3 days post-tumor implantation, and mass was assessed after euthanasia. TPX: tiplaxtinin.

Back to article page