Fig. 4: ChIP-seq analysis shows the effect of CM on H3K9ac/H3K14ac-marked genes. | Cell Death & Disease

Fig. 4: ChIP-seq analysis shows the effect of CM on H3K9ac/H3K14ac-marked genes.

From: Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell

Fig. 4

A Average profile of H3K9ac/H3K14ac peaks binding to TSS region in U87MG cells treated with V or CM for 2 days. B Dysregulated genes with H3K9ac/H3K14ac tags identified by ChIP-seq. C Gene enrichment analysis of genes with altered H3K9ac/H3K14ac tags. Red trace lines indicate adjusted P = 0.05. D Venn diagrams showing gene counts regulated by H3K9ac and/or H3K14ac. E, F Heatmap of genes with altered H3K9ac/H3K14ac tags. G, H Representative peak plot of oncogenes regulated by H3K9ac (MCM1 and MYC). H Representative peak plot of neuron development-related genes regulated by H3K9ac/H3K14ac (GNAQ1 and BMP7). V, Vehicle (1‰ DMSO); C, 0.5 mM 8-CPT-cAMP; M, 1 μM MS275.

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