Fig. 1: The identification of SGK2 promoting PCa metastasis.
From: SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4
A, B Volcano plots showing differential expressed genes (DEGs) of the TCGA-PRAD group dataset and the GSE6752 dataset. (PRAD, prostate adenocarcinoma). C Venn-diagram analysis of upregulated/ downregulated genes in the TCGA-PRAD group dataset and the GSE6752 dataset. D OS, PFS were analyzed according to high or low expression of SGK2 from the TCGA database. The number of patients in low-expression groups are 249, and the number of patients in high expression groups are 250. E Western blotting analysis of SGK2 expression in PCa tissues without lymph node metastasis(N0) and PCa tissues with lymph node metastasis(N1). F Immunohistochemistry (IHC) analysis of SGK2 expression difference and H-scores of SGK2 among PCa tissues without lymph node metastasis(N0) and PCa tissues with lymph node metastasis(N1) and corresponding Lymph Node Metastases tissues. Scale bars, 20 μm. G Transwell analysis of the migration and invasion capability of PCa cells with SGK2 knockdown. Scale bars, 50 μm. Data are presented as representative images or as the mean ± SD of three independent experiments. *P < 0.05; ns, not significant.
