Fig. 7: TMP195 treatment depleted CD11bint F4/80+ TAMs in late-stage CRLMs. | Cell Death & Disease

Fig. 7: TMP195 treatment depleted CD11bint F4/80+ TAMs in late-stage CRLMs.

From: Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis

Fig. 7

Flow cytometry analysis on 14 dpi liver biopsies of the tumor area (A) and liver area (B) with/without TMP195 treatment. TMP195 treatment greatly reduced the number of CD11bint F4/80+ cells whereas increased that of CD11b+ F4/80− cells in the tumors (A, C left) but not the tumor-free livers (B, C right) of CRLMs. D Further flow cytometry analysis on CD11bint F4/80+ (a) and CD11b+ F4/80− (b) cell populations shown in A (the lower panel) indicated mixed expression of M1-like type marker CD86 and M2-like marker CD206 in both CD11b+ or F4/80+ cells. *p < 0.05; **p < 0.01.

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