Fig. 4: ASAP1 promote GC cell migration and invasion in vitro and in vivo. | Cell Death & Disease

Fig. 4: ASAP1 promote GC cell migration and invasion in vitro and in vivo.

From: ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancer

Fig. 4

A, B, C Representative images from transwell assays with MGC-803 and SGC-7901 cells expressing ASAP1-HA, depleted of ASAP1 or partially knocked out of ASAP1. The numbers of migrating and invading cells are presented in the right panel. Scale bar,100 μm. D, E SGC-7901-WT-Luc and ASAP1+/− SGC-7901-Luc were injected into tail veins of nude mice to construct lung metastasis models, respectively, 30 days after injection, metastasis of GC cells in lungs of nude mice was evaluated and quantified. F, G Specimen graphs of lung metastases and statistical graphs of the number of tumors metastasizing in the lungs ns-not significant; *P < 0.05, **P < 0.01, and ***P < 0.001.

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