Fig. 7: Mechanism diagram of ENTPD5 regulating protein N-glycosylation in DKD.
From: The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation
In DKD, hyperglycemia activates the hexosamine biosynthesis pathway (HBP) to promote or inhibit SP1 O-glycosylation via a negative feedback mechanism, thus regulating ENTPD5 expression at the transcriptional level. ENTPD5 regulates unfolded protein N-glycosylation in the ER to promote cell proliferation or apoptosis of renal tubular epithelial cell.
