Fig. 2: Fpn1 knockout in ECs decreases brain iron accumulation and apoptosis associated with the acute stage of ischemic stroke. | Cell Death & Disease

Fig. 2: Fpn1 knockout in ECs decreases brain iron accumulation and apoptosis associated with the acute stage of ischemic stroke.

From: Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke

Fig. 2

Representative western blot images of the levels of FtL, TfR1, FtH and FPN1 (A) in the contralateral (Con) and ipsilateral (Ips) cerebral cortex on Day 1 after dMCAO. Quantification of the western blot signals of FtL (B), TfR1 (C), FtH (D), and FPN1 (F). E Representative western blot images of the levels of Bcl2, Bax, and p-Erk1/2 in the contralateral (Con) and ipsilateral (Ips) cerebral cortex at Day 1 after dMCAO. Quantification of the western blot signals of Bcl2/Bax ratio (G), and p-Erk1/2 (H). β-actin or GAPDH was used as an internal control. The data are presented as the mean ± SD. n = 6, two-way ANOVA, Tukey’s post hoc comparisons, *p < 0.05, **p < 0.01, ***p < 0.001.

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