Fig. 6: Restoration of CRTC2 and CREB rescues impaired SLC2A3-mediated glycolytic defects in TRPM7KO cells. | Cell Death & Disease

Fig. 6: Restoration of CRTC2 and CREB rescues impaired SLC2A3-mediated glycolytic defects in TRPM7KO cells.

From: The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis

Fig. 6

A, B Enhanced SLC2A3 transcripts under the forced expression of SLC2A3, CRTC2-CA (Tyr134Phe) or CREB-CA (Ser171Ala, Ser275Ala) (scale bars, 20 μm). C–F Normalized glucose uptake and glycolysis in lenti-hCREB-CA or lenti-hCRTC2-CA-transduced TRPM7KO cells. Multiple groups were compared by ANOVA.

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