Table 1 The functions of agents targeting inflammatory signaling pathways in ferroptosis-related diseases.

Inhibitors	Signaling pathways	Targets	Effects on ferroptosis	Functions	References
propofol	JAK-STAT	STAT3	exacerbates erastin-induced gastric cancer cell ferroptosis enhances iron content and ROS level, and induces colorectal cancer cell ferroptosis maintains iron homeostasis	represses gastric cancer growth in vivo inhibits colorectal cancer tumorigenesis protects against iron overload-induced nerve cell injury	[55, 56, 63]
artesunate	JAK-STAT	STAT3	enhances erastin-induced ferroptosis	exerts antineoplastic effects in DLBCL cells	[57]
dandelion polysaccharide	JAK-STAT	JAK2-STAT3	reduces the expression of hepcidin	decreases iron burden in tumor tissues	[62]
dimethyl fumarate	NF-κB	NF-κBp65	alleviates oxidative stress and ferroptosis	reduces chronic cerebral-induced neuronal damage and improves cognitive deficits	[72]
loganin	MAPK	ERK	attenuates cisplatin-induced renal tubular ferroptosis	decreases the severity of acute kidney injury	[121]
taxifolin	MAPK	p38 MAPK	reduces liver iron content and enhances redox status	mitigates iron overload-induced hepatocellular injury	[123]
alpha lipoic acid	MAPK	p38 MAPK	decreases MDA level and enhances SOD activity	ameliorates iron sucrose-induced oxidative kidney injury	[124]
resveratrol	MAPK	p38 MAPK	decreases lipid peroxide production and increases antioxidant activities	protects the spinal cord from ischemia injury	[125]
GDC-0879	MAPK	ERK1/2	upregulates GPX4 expression and prevents lipid peroxidation	ameliorates CoQ-deficiency kidney disease	[127]

JAK Janus kinase, STAT Signal transducer and activator of transcription, ROS Reactive oxygen species, DLBCL Diffuse large B cell lymphoma, NF-κB Nuclear factor-κB, MAPK Mitogen-activated protein kinase, ERK Extracellular signal-regulated kinase, MDA Malonaldehyde, SOD Superoxide dismutase, GPX4 Glutathione peroxidase 4, CoQ Coenzyme Q.

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