Fig. 7: Clinical relevance of USP10/RUNX1-driven PMT in human GBM.
From: USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma
A Representative images showing the expression of USP10 and RUNX1 in two matched pairs of relapsed MES and primary PN tumors. B Western blot showing USP10 and RUNX1 levels in primary PN tumors and corresponding relapsed MES tumors. C Correlation between USP10 and RUNX1 in GBM tissues. Progression-free (D) and overall (E) survival of GBM patients with different USP10 expression. F Schematic illustration of main findings of the study, which supports USP10-mediated RUNX1 stabilization promotes proneural-to-mesenchymal transition (PMT) in GBM. ***p < 0.001; ****p < 0.0001.
