Fig. 3: The “yin and yang”effect of ALKBH5 in GI cancer development. | Cell Death & Disease

Fig. 3: The “yin and yang”effect of ALKBH5 in GI cancer development.

From: Aberrant RNA m6A modification in gastrointestinal malignancies: versatile regulators of cancer hallmarks and novel therapeutic opportunities

Fig. 3

The oncogenic ALKBH5 demethylates m6A modified circCPSF6 to promote expression of YAP1 by blunting PCBP2 binding to YAP1 mRNA, to facilitate HCC development. The tumor suppressor role of ALKBH5 is revealed by its loss of expression in HCC and GC, which facilitate the m6A modification of LYPD1 and PKMYT1 contributing to mRNA stabilization and tumor proliferation and invasion in IGF2BP-dependent manner.

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