Fig. 7: Engineered fatostatin NPs enhance the antitumor effects of fatostatin through targeted delivery to GBM cells. | Cell Death & Disease

Fig. 7: Engineered fatostatin NPs enhance the antitumor effects of fatostatin through targeted delivery to GBM cells.

From: Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma

Fig. 7

A The chemical formula of fatostatin, PLGA, and PLGA-PEG-MAL. B Schematic diagram of nanoparticle synthesis. C SEM showed the morphology of NPs-FAT (loaded with fatostatin) and p28-NPs-FAT. D The ζ-potential of NPs-FAT and p28-NPs-FAT. E The mean hydration diameter of NPs-FAT and p28-NPs-FAT. F Cellular uptake assay using free C6, NPs encapsulated C6, and p28-NPs encapsulated C6. G CCK-8 assays showed the cell viability (absorbance value at 450 nm) of U87 and U251 cells after treatment with PBS, fatostatin (FAT), NPs-FAT, or p28-NPs-FAT. H The invasion ability of U87 and U251 cells after treatment with PBS (I), FAT(II), NPs-FAT(III), or p28-NPs-FAT (IV). I The ROS levels of U87 and U251 cells after treatment with PBS, FAT, NPs-FAT, or p28-NPs-FAT.

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