Fig. 3: PDE4D deficiency in the liver improved HFD-induced hepatic steatosis and associated renal damage. | Cell Death & Disease

Fig. 3: PDE4D deficiency in the liver improved HFD-induced hepatic steatosis and associated renal damage.

From: Genetic deletion of phosphodiesterase 4D in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk

Fig. 3

PDE4D-LKO and WT mice were fed a HFD for 16 weeks, and the liver and kidney were collected at week 16. A HE (upper panel) and Oil red O (lower panel) staining of mouse livers at week 16. B The protein levels of PDE4D in kidney tissue of WT and PDE4D-LKO mice. C Phosphorylation of AKT in kidney after mice were injected with insulin for 15 min (n = 6). D Kidney and perirenal fat weight of WT and PDE4D-LKO HFD mice at week 16. E Serum creatinine and BUN levels of the two groups of mice (n = 6). F HE, Oil red O, PAS, and Sirius red staining of mouse kidney. G TUNEL staining in kidney tissue of WT and PDE4D-LKO mice. Data are shown as the means ± SEMs. *P < 0.05, **P < 0.01, ***P < 0.001 by two-tailed Student’s t test.

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