Fig. 2: miR-182 promotes lung cancer bone metastasis in mice. | Cell Death & Disease

Fig. 2: miR-182 promotes lung cancer bone metastasis in mice.

From: A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer

Fig. 2

A, B miR-182 overexpression potently increased the bone-metastatic ability of A549 cells in nude mice. On 4 weeks post-IC injection of negative control (NC) or miR-182-expressing lentivirus (miR-182)-infected A549 cells, the bioluminescence signals of bone-metastatic tumors were detected by BLI (A), and bone damage was measured by micro-CT and quantified by BV/TV (B). C TRAP staining analysis of osteoclast formation at the boundary between bone and metastatic tumor in NC or miR-182 expression A549 cell-injected mice, with TRAP-positive osteoclasts indicated by arrowheads. Scale bars, 50 μm. The average values ± SEM of three separate experiments are plotted. ***P < 0.001.

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