Fig. 6: KLF12 promotes the proliferation of breast cancer cells in vivo. | Cell Death & Disease

Fig. 6: KLF12 promotes the proliferation of breast cancer cells in vivo.

From: KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner

Fig. 6

Five-week-old female BALB/C nude mice were inoculated with ZR-75-30 cells transfected with indicated plasmids; cells were injected in the right mammary fat pad. After 45 days, the mice were sacrificed, and the tumors were dissected, photographed, and weighed. a Image showing the sizes of tumors in xenograft mice. b, c Weight and volume of tumor-induced in mice by subcutaneously implanted ZR-75-30 cells, in which the KLF12 had been knockdown by shKLF12#1 or NC. Data are presented as means ± SDs (p < 0.05, significant; ns, not significant; *p < 0.05; **p < 0.01). d MTT assay showed the growth curves of ZR-75-30 cells with the indicated plasmid. Data are presented as means ± SD. (p < 0.05, significant; ns, not significant; *p < 0.05; **p < 0.01). e Kaplan–Meier curve of relapse-free survival times of breast cancer patients stratified by KLF12 expression levels. p = 0.00027 < 0.05. These data were obtained from http://kmplot.com/analysis/.Statistical significance was determined by the log-rank test.

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